Transportation in Turkey is mostly done by bus. The buses are comfortable and like in the plane a host/hostess presents you something to eat or drink all along the way. Short breaks are given on the way depending on the length of the journey. Especially for last few years the highways in Turkey are in better condition that is why it is easier to travel by bus. The other advantage that bus travel gives you is to see more places on the way.
When you are on Holiday in Istanbul if you would like to make any of your trips by bus here is the timetable for it.